Tuesday, April 30, 2013

From the mail bag: Why does my 16GB Galaxy S4 only have 8.8GB of space?

Galaxy S4

More features mean more spaced used for their files, and the Galaxy S4 takes about twice the storage space as the previous model

Morris writes in, 

I just got myself a Samsung Galaxy S4 (16GB). Upon further storage checking, I noticed the Total Space is only 8.82GB. I am confused. How much memory space actually does Jelly Bean 4.2.2 take?

There sure has been a lot of discussion about the remaining storage on the Galaxy S4's 16GB "disk" after the factory software is accounted for. We're used to seeing a bit of discrepancy between what is advertised and what's really available, but this go 'round the difference is huge and has quite a few people a bit concerned. Morris gets to the root of the issue with his question, once you have a look at what's going on.

The Samsung Galaxy S4's system folder, the one where all the magic happens and the factory installed "stuff" resides takes over 2GB of space (2,235,535,360 bytes for those that like numbers). Compared to the Jelly Bean system files on the Galaxy S3 at 1.1GB, and the Nexus 4 at 495MB, that's quite a bit of difference. By the time you take the rest of the OS into account, and partition space reserved for things like the system cache, that leaves you with about half the advertised space left to use for your own stuff.

We're not going to knock on Samsung for using so much space for the operating system. When you want features included as part of the OS, you need to have the files somewhere. Samsung brings features to the Galaxy S4 that you won't find anywhere else, and the cost of those features is reduced storage left for the user. You also won't find these features on Google Play, so this is the trade-off you have to make. 

Also, there's the SD card slot to remember here as well. While this won't help you when you run out of space to install applications, you can store all your multimedia and documents there. 13MP panorama pictures and 1080p video can take a lot of room, so storing your camera shots on the SD card is a good idea. 

Right now, nobody seems to be selling the 32 or 64GB versions of the Galaxy S4. We're not sure if Samsung is at fault here, or the carriers around the world, but no matter who we point a finger at they just aren't available. In the meantime, 8.8GB is enough for some folks, and for some it's not. Until we start to see the models with more storage become available, this is how it is.

We can't tell you that this does or doesn't matter to you, you'll have to decide that one for yourself. 

    


Source: http://feedproxy.google.com/~r/androidcentral/~3/TuVnRBVerQk/story01.htm

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Life is Good: Musings and Ramblings: Unexpectedly Blessed

(originally written Thursday, April 26, 2013)?

The days. ?They are so short, go by so quickly. ?Somehow Max is over halfway to his first birthday, and my baby bug is going to be 3 years old in 4 short months. ?What?! ?How did this happen?

I try to absorb each day; each blessed day I get to be with them, to play with them, clean up their messes, and help them reach new goals. ?Many days are calm, fun, and messy. ?Others are hectic, tear filled, and more than messy. ?That's what it's about though, right? ?I mean, whether you are home all day with your children or you work outside the home, life is all about the messy moments- whether they are controlled chaos or full blown out of control, whirlwinds.

It's hard. ?I've never done something that was so challenging in my life.?except maybe learn how to drive a stick, at which I was never successful ..? There are days I need more control than I have, and others that I let go and just let it happen. ?Those days, I have learned, are the easiest. ?This morning J.Tom, Lexie, and I sat on the bed. ?I handed her milk and declared today a NO housework day. ?No laundry, no vacuuming, no house work day. ?I've cleaned up the crumbs, and picked up toys after we played with them. ?The rest of the time all my attention was with the kids. ?I say my attention was "with" them, not on?them because though I was there watching and interacting I wasn't hovering.

Sometimes I wonder if stay at home moms are misunderstood? ?Not that it matters, we all know why we are home with our babies, no matter the reason. ?But sometimes comments from others makes me wonder, what do they think we do all day? ?What kind of person do they think I am?!? We don't lay on the couch all day watching tv. ?It's not so I can micro manage their lives and create a perfect specimen. ?On the contrary, for our family being home is about soaking in all the mistakes and character flaws, then turning them into lessons later. ?Not to mention just the time we absorb together, as a family, learning about the each other, Christ, the world. ?But you know, being a parent is somewhat about controlling what your children are exposed to, how they're exposed to it, and at what age. ?If I am going to take full responsibility for my children, I think JTom and I probably need to take control of the paths we lead them down. ?I never wanted a family; my dream at 15 was to become a forensic pathologist and move to California where I would live in a house by myself, or with my best friend at the time, and live a lavish lifestyle. ?None of those things happened... my best friend went to medical school. ?I graduated highschool early, partied until I absolutely burned myself out, started college, met and totally unexpectedly fell in love with Jtom. ?And then everything else just happened. ?Nine years later we are married and have two children. ?Nine years of blessings and growing together.

Blessings abound all around our family; we have been talking more and more about those blessings to Lexie. When she is refusing to eat her favorite food, simply because she is being defiant not because she isn't hungry, I explain that not every girl and boy get lunch every day. ?Or even food every day. The same goes for braiding her hair- not every girl has a mama to braid her hair, or give her a warm, clean bath. ?Those seem like silly examples, but she understands them. ?She's 2.5 but she knows there is a world outside our four walls, and that some of that world isn't as nice as hers. ?She will smile and say, "Jesus gave me a mommy and daddy and max and lunch!" ?*warm tingly feeling* ?(insert an edit: we went to the library this morning for story time. ?She told a mom there that "Jesus gave me a beautiful daddy." ?The mom responded with, that's right. ?Not every girl and boy have a daddy. ?You are so blessed.")

Then there are moments when I feel completely overwhelmed, asking myself what am I doing?!? How am I supposed to fit God, meals, play, learning, cleaning, and serving my husband- joyfully- all in 24 short hours? ?7 of which need to be filled with sleep, so that I am able to serve my family. ?This morning I was in the pantry deciding which lunch bag to take on our picnic play date with J.Tom this afternoon. ?As a million plastic cups fell out of the lunch bag I'd chosen, I took a deep breath and looked around. ?I was standing in a pantry the size of a bathroom, filled to the brim with food for our family and craft supplies for Lexie. ?I'm not sure what we have done to deserve the blessings we have been given. ?We have a home big enough for the family we hope to continue growing. ?It's warm in the winter and (hopefully) cool in the summer. ?You can't feel the cold air blowing from the cracks in the doors and windows. ?The floors are safe and comfortable for the babies to play on. ?We have clean, running water, toilets that work (hallelujah!), and silent pipes! (meaning no clanging and banging in the walls that wakes up sleeping babes! ?We can flush the toilet after 7pm woo hoo)

Our old home wasn't bad, it was a blessing as well; just a blessing that needed many hours and dollars worth of fixing up. ?We now live in a neighborhood with other young families. ?Our home is one street from the disc hockey park and community pool (which is more like a mini water park) so there are many places to run and play during these beautiful warm days. ?The people in Nebraska- beyond kind. ?I've not met one rude person, everyone waves and stops to talk. ?Blessings. ?They seem simple, but at the end of the day that went all too quickly, when my clothes are stained with spit up, and my hair is falling out of it's messy pony tail, ?this is what it's about.? It's not about excess. ?It isn't about more than we need (though we do have more than we need in many ways). ?It isn't about which group of friends you are a part of, or how many vacations you go on a year. ?It's about how we spend our days, day in and day out, with each other. ?It's about our kind words, soft smiles, and oh. em. gee. ?the hugs and kisses. ?It's about Max finally learning to fall onto his booty from standing up or almost?saying "mama," but it comes out "na-na."??It's about Lexie learning to write an M on her paper, reciting Bible stories to her brother, and showing him the "Moses's river" she made at the park.

Today, like I mentioned, we met JTom at the park for lunch. ?He ate with us, played with Lexie and then headed back to work. ?We hung around for an hour longer; Lexie played with a little girl. ?Her mama was with her, and being followed by a court appointed supervisor. ?The?supervisor was wearing a badge, and mama wasn't wearing much of anything. ?Much to my first?impression-ed?surprise, she was amazing?with the kids. She was down in the sand, building a mote and castle with them (which encouraged me to do the same). ?She had Lexie and her daughter sharing toys, helping each other. ?I probably seemed like a terrible mom, because I just sorta sat back in awe. ?This woman, in her skinny jeans and barely there top that matched her platinum blonde hair, seemed educated, funny, and in general like a good mom (not that any of those things would make her a bad mom-don't misunderstand me. ?I was thrown off mostly by the supervisor needing to be there). ?She invited us to play with them and their chalk, she made pictures with the girls, and even started acting out Lexie's favorite story on the playground bridge- The Three Billy Goats Gruff... ?I'm not sure where her life ?has been or where it is going, but today from 12:00-12:45pm I am pretty sure it was meant to cross paths with ours. ?On a day when Lexie and I were both feeling a little lonely, wanting a friend to play with at the park (Dayla and Ryker- we miss you!), she and her girl were a blessing. ?Looking back, I am not sure I had quite the same impact on her as she did on me. ?But I do pray that whatever her situation is, she can find more joy in park play dates with Kera, than she does in whatever got her supervised visitations.

We have had a beautiful, fun day today. ?I cannot wait to see what other blessings are in store for our family in the days to come. ?The great thing about blessings, you can't just sit back and wait for them; you have to put yourself out there, serve others, and get uncomfortable sometimes. ?This introvert has learned a lot about that in the last 2.5 years. ?(I know this post was rambly. ?I warned you in the title!)


How have you been unexpectedly blessed this week? ?

Source: http://megswlifeisgood.blogspot.com/2013/04/musings-and-ramblings-unexpectedly.html

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Monday, April 29, 2013

Rare Diseases Obscured by Shadows of 'Popular' Ills: Op-Ed

Laurie Edwards, lecturer in health and science writing at Northeastern University and author of In the Kingdom of the Sick: A Social History of Chronic Illness in America,?contributed this article to LiveScience's Expert Voices: Op-Ed & Insights.

After a lifetime of infections, hospitalizations and surgeries, a set of lab results changed everything for me. When I was 23, biopsies of my cilia ? the tiny structures that line the respiratory tract ? confirmed that I had a genetic respiratory disease called primary ciliary dyskinesia, or PCD. In patients with PCD, the cilia don't beat properly, so clearing secretions is more difficult and infections and decreased oxygenation are common.

Haven't heard of PCD? That's no surprise; even when I'm in the hospital, I sometimes have to both spell and define it for health care professionals who don't see it often, if ever. About 400 patients have been correctly diagnosed with PCD, though an estimated 25,000 Americans are suspected to have it.?

Getting the correct diagnosis meant my label finally reflected my actual experiences of illness. Without proper treatment, the more advanced my disease became, and the more disruptive my symptoms were. While the disease-specific details may differ, long diagnostic journeys are an unfortunate but inevitable reality for rare disease patients. Research suggests we wait an average of seven years to receive diagnoses. [The 9 Most Bizarre Medical Conditions]

All told, nearly 7,000 rare diseases affect some 30 million Americans, and eighty percent of them are genetic.? Rare, or orphan, diseases are those that affect fewer than 200,000 patients, so there are many of us spread out across relatively small population pools. If doctors and nurses don't always know what I have and what it means, you can imagine the blank stares I get in public, or the sideways glances when people hear my "productive" cough.

Our culture celebrates cause-related marketing of popular diseases through charity events, national awareness months, and the purchasing of consumer products. Rare disease patients are simply not going to see the type of corporate sponsorships and marketing in the name of awareness and research for cures that patients with more common conditions receive.

We do have some tools at our disposal, however. This spring marks the 13th anniversary of the Orphan Drug Act (ODA), legislation that provides necessary financial incentives for companies developing treatments for rare disease populations. Consider this: the National Organization for Rare Disorders (NORD) reports that in the decade prior to the ODA's passage, only 10 drugs were developed. In the thirty years since, the FDA has approved 400 drugs for patient use, and an estimated 2,700 drugs are in the research pipeline.

In 2009, the National Institutes of Health (NIH) launched its own integrated drug-development pipeline named Therapeutics for Rare and Neglected Diseases (TRND). This collaborative program connects NIH researchers, pharmaceutical and biotech companies, and nonprofit organizations and "bridges the gap that often exists between a basic research discovery and the testing of new drugs in humans."

Yet much work remains. The majority of rare diseases still do not have treatments; according to some industry estimates, less than 5 percent have FDA-approved therapies. Many existing therapies are expensive, and healthcare coverage can be more difficult to receive given the lack of standard guidelines on rare and poorly understood diseases.

Of course, patients can only access whatever treatments exist if they are appropriately diagnosed in the first place. Diagnosis does more than validate the experiences of patients. It confers membership to a community of patients and advocates who are working to improve diagnoses, therapies and, hopefully, find curative treatments.

Patients have utilized the Internet and social media platforms to share information on participating in clinical trials, advocate for increased funding and build momentum. From crowd-sourced funding for rare-disease research projects to companies like Rare Genomics, a nonprofit that collaborates with scientists to give patients with rare diseases access to genome sequencing and helps them raise funds for research, there is variety in this momentum. Considering that most rare diseases are genetic, this type of information could prove of incredible valuable.

Now that I know I have PCD, I have preventive daily chest physiotherapy to help clear my lungs and a more effective antibiotic regimen. I spend less time in the hospital, and more time living a more productive life. Without the technology to study cilia, I might still remain a medical puzzle. There is some exciting research underway to develop a genetic test-panel for PCD, and I can't help but think of the thousands of potential PCD patients who could benefit from it.

Focused collaboration between patients, nonprofits, and researchers ? collaboration augmented by the ODA and other programs ? will give us more of the answers we need. For patients who live outside the reach of mainstream fundraising and awareness, this collaboration is empowering.

The views expressed are those of the author and do not necessarily reflect the views of the publisher.?

Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://news.yahoo.com/rare-diseases-obscured-shadows-popular-ills-op-ed-124151485.html

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Visitors and residents: Students' attitudes to academic use of social media

Apr. 29, 2013 ? University of Leicester-led research has shown that university students behave very differently when using social media as part of their academic learning.

Some students happily use social networking to share information about their course with their peers, in a similar way to how they might talk to friends on Facebook.

Others are much more targeted in their use of online tools -- and will only log on to get the information they need, when they need it.

For the study, all 257 undergraduate students in the University's School of Biological Sciences were asked to use the social media site Google+ as part of a key IT and numeracy skills module.

The students were able to discuss parts of the module on the site.

At the end of the term, the students had contributed thousands of posts and hundreds of thousands of words to Google+.

The researchers analysed these contributions, along with students' responses to a questionnaire about how they found the module.

They analysed the contribution to find out what users were talking about, and who was talking to whom. They also analysed the results from the questionnaire to find out why users communicated as they did.

They found that there were significant differences between students' use of social media -- and individual participants displayed "Visitor" and "Resident" characteristics.

The Visitors and Residents model for online engagement was put forward by University of Oxford researchers David White and Dr Alison Le Cornu in 2011.

In this model, "Visitors" use the internet in functional terms as a tool, while "Residents" see the Internet as a social space.

The University of Leicester-led study suggests the Visitors and Residents model is valid -- and is the first study to suggest this using statistical methods.

Fiona Wright conducted the study as part of her final year project of her Biological Science degree.

She said: "In order to know how to effectively teach using social media one needs to understand the student's motivation to use it. Such paradigms, if proven correct, help educators to approach this problem, increasing student engagement with tasks.

"Students of today often spend a large amount of their free time using social media, so if this tool could be used effectively for academic purposes it would be a great resource for teachers in higher education."

The paper was co-written with Dr Alan Cann, a senior lecturer in the Department of Biology -- who leads the IT and Numeracy Skills for Biologists module.

Dr Alan Cann said: "Although social media forms a prominent part of most student's lives and is increasingly becoming part of academic environments, there has been little work investigating how students use and respond to social networks for formal academic purposes (as opposed to informal use).

"This is some of the first evidence which validates the Visitors and Residents model, and so it gives important insights into students reactions to social tools as part of a working environment.

"Although the Visitor and Resident labels only represent the extremes of a continuum of behaviour, this study has produced statistical evidence that Residents report online tools to be more useful academically than Visitors do.

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Story Source:

The above story is reprinted from materials provided by University of Leicester, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Fiona Wright, David White, Tony Hirst, Alan Cann. Visitors and Residents: mapping student attitudes to academic use of social networks. Learning, Media and Technology, 2013; : 1 DOI: 10.1080/17439884.2013.777077

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/living_well/~3/tK2kysxXFDM/130429094946.htm

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Fire destroys Danish museum, artifacts saved

Museum officials say a fire is blazing through The Museum of Danish Resistance in Copenhagen, destroying large parts of the building.

They said Sunday that no one has been injured in the fire and firefighters and staff that rushed to the scene managed to save the majority of artifacts.

The fire started in the museum cafe early Sunday and quickly spread to the exhibition hall. The cause is not yet known.

The museum exhibits objects related to the Danish resistance to the German occupation during World War II.

Source: http://news.yahoo.com/fire-destroys-danish-museum-artifacts-saved-101522727.html

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Can a Phone Do What Your Doc Does?

Apr 27, 2013 7:00am

ht smartphone doctor ll 130426 wblog  Can a Smartphone Do What Your Doctor Does?

Dr. Meera Dalal tests a smartphone app that measures blood pressure at TEDMED. (Image courtesy TEDMED)

By Meera Dalal, M.D.

During our medical training, we?re taught to gather and use information from three sources: a patient history, a physical exam and lab tests. By far the most difficult to master is the physical exam. A good exam requires knowledge of anatomy and physiology, and awareness of normal variations that allow a doctor to recognize abnormalities.

Technology can help, and at TedMed 2013, the SmartPhone Physical exhibit by MedGadget/Nurture showcased some of the latest advances. The goal was to bring complex tests that are?pricey?to perform with traditional equipment into primary care clinics.

The result: accessible, affordable $200 phone accessories, most of them approved by the U.S. Food and Drug Administration as ?equivalency standards,? meaning they?re equal to the industry standard. This technology could improve access to these tests, cut down on referrals, and provide overall better care.

?It?s great for primary care physicians, new doctors with less experience, teaching and even some patients,? said Shiv Gaglani, a medical student at Johns Hopkins and curator of the exhibit. ?Some physicians can go through their entire training without really learning to look into an eye.?

But I was skeptical. In medicine, we learn to question everything. If my own mother came to me saying hugs were good for a cold, I would take the hug, then ask to see the evidence.?So I decided to try it out. Gaglani would be my ?doctor? for this 10-minute exam using the following gadgets:

Blood Pressure Monitor by Withings and Blood Oxygen Monitor by iSp02

We started off, like in all physical exams, by taking the vital signs: blood pressure, heart rate, and oxygenation. The screen buzzed with colorful readings and real-time measurements, and then uploaded my information into an iPad, where I could get it through an app.? It was a start, but I?wasn?t?that impressed. The technology for ?automated vital signs? had been around for a while, and a few years ago I taught my 7-year-old cousin how to use the machine on my grandmother.

ECG Cellphone Case by AliveCor

By squeezing my thumbs onto the metal plates of this iPhone cover, I was able to get a partial ECG that was uploaded and emailed to me. Interesting! One of the problems physicians have is that patients with heart symptoms often improve and the ECG normalizes by the time they see the doctor. This device was simple enough that patients with?symptoms?could get this cell phone case and be taught how to use it. So the next time symptoms occurred, we could get an ECG from during the cardiac event. One of the women who tried it earlier had palpitations during her exam and was diagnosed with a rhythm abnormality.

iExaminer by Welch Allyn

The eye exam, or ?fundoscopy,? is the only way we can look directly at blood vessels inside the body without having to cut anything open. It can tell us a lot about diseases such as high blood pressure and diabetes. Unfortunately, it takes a lot of practice, so many of us end up referred to an ophthalmologist. The iExaminer was able to take an impressive visual photo of the inside of my eye and turn it into a .pdf.

SpiroSmart

This smartphone looked at lung function, which usually is?tested at a special lab during an uncomfortable exam. Guidelines for chronic lung diseases such as asthma, cystic fibrosis and chronic obstructive pulmonary disease ?suggest these tests should be done regularly, but because it is often inconvenient to make a separate trip, they?re ?underused. It would be great if these tests were more accessible.

?Unlike the lab machine, which uses pressure, this device uses sound and has been shown to be almost as accurate,? said SpiroSmart co-creator?Mayank Goel. ?This opens up so many doors; imagine even being able to do this test over the phone!?

Other devices included ThinkLabs? ds32A digital stethoscope that records body sounds (like heart murmurs), the MobiUS SP1 handheld ultrasound machine that looked at the carotid arteries in the neck and was surprisingly accurate compared to the full ultrasound machines, and an otoscope that looked at my eardrum and took a picture.

Overall, I was grudgingly impressed. The devices seemed to combine the best parts of human experience and technology, using technology to gather reliable information, especially for those with less experience, and the physician to interpret the results.

Studies looking at ?inter-rater reliability,? the concept of how likely is it that different people interpreting the same physical exam sign will get the same diagnosis, show that technology is often better for gathering consistently objective information.

The long lineup at the SmartPhone Physical Booth at TedMed included the surgeon general and Dr. Daniel Kraft, faculty chair of medicine at Singularity University in San Diego, who was impressed by the? potential for improving access to care, whether in remote areas or overseas.

?It can enable primary care anywhere. And even though we need to do more testing to ensure accuracy, the potential is great,? Kraft said.

One of the problems, however, is that each device has to be attached to the phone in a separate way, and data is uploaded to different apps, creating a huge amount of information to sift through.

?Our ability to gather data is overtaking our ability to pare it down and use it to improve our health,? said?TedMed editor-in-chief?John Benditt.

And it?s true. The creation of complex devices and technology is surpassing our ability to learn it and use it to its full potential before the ?next big thing? comes out. What I?d really like to see is an ECG machine and BP machine that combines data with the lung machine and uploads it to the same profile. Arguably, the next big challenge in medicine may not be the creation of new technology but finding a way to integrate existing ones.

Source: http://abcnews.go.com/blogs/health/2013/04/27/can-a-smartphone-do-what-your-doctor-does/

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Sunday, April 28, 2013

Yeah, well, the not-nice-words store called, and they?re running out of you (Unqualified Offerings)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories Stories, RSS and RSS Feed via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/301912940?client_source=feed&format=rss

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Fit Planet Week 29th April ? 3rd May | Woodhead Primary School

Next week our children will be taking part in a variety of indoor and outdoor activities to promote their fitness, health and wellbeing. They will also be taking on ?eco challenges? to raise awareness of environmental issues. There will be healthy eating workshops, Bollywood dancing, a mobile adventure course, fencing and cycle tracks to try. Make sure your child comes to school with a waterproof jacket incase it rains when they are outside on activities. We are looking forward to a whole lot of fun!

Source: http://www.woodhead-primary.org.uk/fit-planet-week-29th-april-3rd-may/

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Obama backs Planned Parenthood in political fight

WASHINGTON (AP) ? President Barack Obama vowed Friday to join Planned Parenthood in fighting against what he said were efforts across the country to turn women's health back to the 1950s.

Obama's comments were the first by a sitting president before the abortion-rights group. He lauded its nearly 100 years of service to women, providing cancer screenings, contraceptives and other health services.

"When politicians try to turn Planned Parenthood into a punching bag, they're not just talking about you," he said. "They're talking about the millions of women who you serve."

Obama asserted that "an assault on women's rights" is underway across the country, with bills being introduced in nearly every state legislature to limit or ban abortion or restrict access to birth control.

"The fact is, after decades of progress, there's still those who want to turn back the clock to policies more suited to the 1950s than the 21st Century," Obama said. "And they've been involved in an orchestrated and historic effort to roll back basic rights when it comes to women's health."

Obama says he fought for his health care law to ensure individuals have the right to make their own medical choices. He's asking medical providers and abortion rights supporters to "get the word out" about the law's benefits.

He encouraged those gathered to continue fighting for abortion rights. "You've also got a president who is going to be right there with you, fighting every step of the way," Obama said.

Source: http://news.yahoo.com/obama-backs-planned-parenthood-political-fight-163153869.html

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Saturday, April 27, 2013

Boosting the powers of genomic science

Friday, April 26, 2013

As scientists probe and parse the genetic bases of what makes a human a human (or one human different from another), and vigorously push for greater use of whole genome sequencing, they find themselves increasingly threatened by the unthinkable: Too much data to make full sense of.

In a pair of papers published in the April 25, 2013 issue of PLOS Genetics, two diverse teams of scientists, both headed by researchers at the University of California, San Diego School of Medicine, describe novel statistical models that more broadly and deeply identify associations between bits of sequenced DNA called single nucleotide polymorphisms or SNPs and say lead to a more complete and accurate understanding of the genetic underpinnings of many diseases and how best to treat them.

"It's increasingly evident that highly heritable diseases and traits are influenced by a large number of genetic variants in different parts of the genome, each with small effects," said Anders M. Dale, PhD, a professor in the departments of Radiology, Neurosciences and Psychiatry at the UC San Diego School of Medicine. "Unfortunately, it's also increasingly evident that existing statistical methods, like genome-wide association studies (GWAS) that look for associations between SNPs and diseases, are severely underpowered and can't adequately incorporate all of this new, exciting and exceedingly rich data."

Dale cited, for example, a recent study published in Nature Genetics in which researchers used traditional GWAS to raise the number of SNPs associated with primary sclerosing cholangitis from four to 16. The scientists then applied the new statistical methods to identify 33 additional SNPs, more than tripling the number of genome locations associated with the life-threatening liver disease.

Generally speaking, the new methods boost researchers' analytical powers by incorporating a priori or prior knowledge about the function of SNPs with their pleiotrophic relationships to multiple phenotypes. Pleiotrophy occurs when one gene influences multiple sets of observed traits or phenotypes.

Dale and colleagues believe the new methods could lead to a paradigm shift in CWAS analysis, with profound implications across a broad range of complex traits and disorders.

"There is ever-greater emphasis being placed on expensive whole genome sequencing efforts," he said, "but as the science advances, the challenges become larger. The needle in the haystack of traditional GWAS involves searching through about one million SNPs. This will increase 10- to 100-fold, to about 3 billion positions. We think these new methodologies allow us to more completely exploit our resources, to extract the most information possible, which we think has important implications for gene discovery, drug development and more accurately assessing a person's overall genetic risk of developing a certain disease."

"All SNPs are not created equal: Genome-wide association studies reveal a consisten pattern of enrichment among functionally annotated SNPs." Authors include Andrew J. Schork, UCSD Cognitive Sciences Graduate Program, UCSD Center for Human Development and UCSD Multimodal Imaging Laboratory; Wesley K. Thompson and John R. Kelsoe, Department of Psychiatry, UCSD; Phillip Pham, Scripps Health, The Scripps Research Institute (TSRI); Ali Torkamani and Nicholas J. Schork, Scripps Health, TSRI; J. Cooper Roddy, UCSD Multimodal Laboratory; Patrick F. Sullivan, University of North Carolina; Michael C. O'Donovan, Cardiff University, United Kingdom; Helena Furberg, Memorial Sloan Kettering Cancer Center; The Tobacco and Genetics Consortium, The Bipolar Disorder Psychiatric Genomics Consortium, The Schizophrenic Psychiatric Genomics Consortium; and Ole A. Andreassen, UCSD Department of Psychiatry, University of Oslo and Oslo University Hospital.

"Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional False Discovery Rate."

###

University of California - San Diego: http://www.ucsd.edu

Thanks to University of California - San Diego for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127968/Boosting_the_powers_of_genomic_science

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Alleged 9/11 airplane part to be examined

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Source: http://feeds.nbcnews.com/c/35002/f/653381/s/2b3a0a2c/l/0Lvideo0Bmsnbc0Bmsn0N0Cid0C51682533/story01.htm

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Artificial sense of touch gets smarter, lets robots really feel

Artifical sense of touch gets smarter, lets robots really feel

The verdict's still out on whether or not androids dream of electric sheep. But their ability to feel? Well, that's about to approach levels of human sensitivity. We're of course talking about the sense of touch, not emotions. And thanks to work out of Georgia Tech, tactile sensitivity for robotics, more secure e-signatures and general human-machine interaction is about to get a great 'ol boost. Through the use of thousands of piezotronic transistors (i.e., grouped vertical zinc oxide nanowires) known as "taxels," a three-person team led by Prof. Zhong Lin Wang has devised a way to translate motion into electronic signals. In other words, you're looking at a future in which robotic hands interpret the nuances of a surface or gripped object akin to a human fingertip and artificial skin senses touch similar to the way tiny hairs on an arm do.

What's more, the tech has use outside of robotics and can even be levereged for more secure e-signature verification based on speed and pressure of a user's handwriting. And the best part? These sensors can be manufactured on transparent and flexible substrates like the one pictured above, which allows for various real-world applications -- just use your imagination. Pretty soon, even robots will have the pleasure of enjoying the touch... the feel of cotton and maybe even hum that jingle to themselves, too.

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Via: MIT Technology Review

Source: Georgia Tech, Science

Source: http://www.engadget.com/2013/04/26/artificial-sense-of-touch-gets-smarter-lets-robots-really-feel/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Friday, April 26, 2013

CA-BUSINESS Summary

TSX slides as mining, energy issues stumble

TORONTO (Reuters) - Canada's main stock market finished lower on Friday as natural resource stocks slumped and market sentiment soured following U.S. economic growth data that fell short of expectations. U.S. gross domestic product expanded at a 2.5 percent rate, an increase from the fourth quarter's dismal 0.4 percent pace but shy of the 3 percent growth analysts were hoping for. The weaker-than-expected data in Canada's biggest trading partner weighed on Canadian stocks.

Vodafone investors want bigger bid or full takeover by Verizon

LONDON (Reuters) - Six major Vodafone investors said $100 billion was not enough for the British company's stake in its U.S. joint venture with Verizon Communications , and urged the latter to come up with an offer of at least $120 billion. Their comments followed a Reuters report on Wednesday that Verizon had hired advisers to prepare a possible $100 billion bid to buy Vodafone's 45 percent stake in their Verizon Wireless joint venture, likely to be structured as a roughly 50:50 cash and stock bid.

Exclusive: Brazil's Vale says signs accord to quit Argentine Potash project

RIO DE JANEIRO (Reuters) - Global miner Vale SA signed an agreement with the Argentine government on Friday that will allow the Brazilian company to leave the $6 billion Rio Colorado potash mining project, a company spokeswoman told Reuters on Friday. The agreement could put an end to months of uncertainty for Vale , which suspended work on the fertilizer project in December and announced its intention to pull out in March.

TransCanada sees Keystone XL delayed till second-half 2015

CALGARY, Alberta (Reuters) - TransCanada Corp , Canada's No. 2 pipeline company, said on Friday the long wait for U.S. government approval of its controversial Keystone XL project will further delay completion of the pipeline and push its cost above the company's $5.3 billion estimate. TransCanada, which reported a 27 percent rise in first-quarter profit on Friday, is waiting for the Obama administration to issue a presidential permit for construction of the line, which is designed to carry 830,000 barrels a day of Canadian and U.S. crude oil to refineries on the Gulf of Mexico coast.

U.S. sues Novartis over kickbacks, second case this week

NEW YORK (Reuters) - The U.S. government on Friday announced its second civil fraud lawsuit against Novartis AG in four days, accusing a unit of the Swiss drugmaker of paying multimillion-dollar kickbacks to doctors in exchange for prescribing its drugs. Authorities said the Basel-based company for a decade lavished healthy speaking fees and "opulent" meals, including a nearly $10,000 dinner for three at the Japanese restaurant, Nobu, to induce doctors to prescribe its drugs.

Chevron profit pinched by cheaper oil, but beats estimates

(Reuters) - Lower oil prices bit into Chevron Corp's quarterly profit as did refinery downtime and higher operating costs in its home market, but the oil company's shares rose as the earnings topped expectations. Analysts cited foreign currency gains that gave the company a particular boost in the quarter.

Mothers group petitions Disney over sick pay laws

ORLANDO, Florida (Reuters) - Representatives of a national organization of mothers were prevented on Thursday from delivering a petition to Walt Disney World accusing it of trying to block laws that would require companies to provide paid sick leave for employees. "They were turned away and security was called," Kristin Rowe-Finkbeiner, executive director of MomsRising, told Reuters on Friday.

Valeant in talks to buy Actavis for over $13 billion: WSJ

(Reuters) - Canada's biggest listed drug maker, Valeant Pharmaceuticals International Inc , is in talks to buy generic drugmaker Actavis Inc for more than $13 billion, Wall Street Journal reported, citing people familiar with the matter. The companies had been working towards an all-stock deal, when some of Actavis' directors came out against it around the middle of this week. But executives on the two sides are still working to resurrect the deal, the journal said.

Dollar falls against the yen; bond yields decline

NEW YORK (Reuters) - The U.S. dollar tumbled against the yen on Friday after the Bank of Japan left its monetary policy unchanged, while benchmark U.S. bond yields fell to near 4-1/2-month lows after the U.S. economy grew less than expected in the first quarter. The disappointing growth rate spurred concerns about a tepid outlook for the United States which, along with recent concerns that China's growth is slowing, also hit the price of oil. Brent crude fell to just above $103 a barrel after rising $3 in the past two sessions.

Portugal to challenge JPMorgan, Santander swaps in court

LISBON (Reuters) - Portugal's government said on Friday it would challenge in court several high-risk hedge contracts signed by public companies and banks JPMorgan and the local unit of Spain's Santander to avoid losses for the debt-ridden state. Treasury Secretary Maria Luiz Albuquerque said the government had managed to renegotiate some swap contracts containing "highly speculative elements" with other banks, cutting by 20 percent potential liabilities from swaps that could total 3 billion euros ($3.9 billion).

Source: http://news.yahoo.com/ca-business-summary-000259603.html

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This is the Modem World: Nothing is new. It's been done before.

Each week Joshua Fruhlinger contributes This is the Modem World, a column dedicated to exploring the culture of consumer technology.

DNP This is the Modem World Nothing is new It's been done before

It's funny how things come back around. When I was growing up in the '80s, music was looking back at the '50s and '60s and re-creating it into some of the best bands the world has seen. Paul Weller wouldn't have become the songwriter he is had he not grown up on the Beatles. Likewise, Paul McCartney wouldn't have become the genius that he is had he not been raised on Little Richard. And now, bands are looking back at the '80s and re-doing that explosive era -- with both good and bad results that I will not go into here lest I make new enemies.

Culture is cyclical, and we're beginning to see that technology is bound to follow that same rinse-and-repeat formula.

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Source: http://www.engadget.com/2013/04/24/nothing-is-new-its-been-done-before/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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PFT: Team-by-team NFL draft needs

FisherGetty Images

We had an initial mock draft because everyone does.

We had a second version of the mock draft because everyone does.

And now we have a final version of the mock draft because I?ve got nothing else to do tonight.

We welcome your comments, criticisms, and questions regarding our sanity.

1.? Chiefs:? Eric Fisher, tackle, Central Michigan.

2.? Jaguars:? Luke Joeckel, tackle, Texas A&M.

3.? Raiders:? Sharrif Floyd, defensive tackle, Florida.

4.? Eagles:? Dion Jordan, defensive end, Oregon.

5.? Lions:? Ezekial Ansah, defensive end, BYU.

6.? Browns:? Dee Milliner, cornerback, Alabama.

7.? Cardinals:? Lane Johnson, tackle, Oklahoma.

8.? Bills: Ryan Nassib, quarterback, Syracuse.

9.? Jets:? Barkevious Mingo, defensive end, LSU.

10.? Titans:? Chance Warmack, guard, Alabama.

11.? Chargers:? Johnathan Cooper, guard, North Carolina.

12.? Dolphins:? Desmond Trufant, cornerback, Washington.

13.? Jets:? Tavon Austin, receiver, West Virginia.

14.? Panthers:? Star Lotulelei, defensive tackle, Utah.

15.? Saints:? Xavier Rhodes, cornerback, Florida State.

16.? Rams:? Cordarrelle Patterson, receiver, Tennessee.

17.? Steelers:? Jarvis Jones, linebacker, Georgia.

18.? Cowboys:? ?Sheldon Richardson, defensive tackle, Missouri.

19.? Giants:? Tyler Eifert, tight end, Notre Dame.

20.? Bears:? Sylvester Williams, defensive tackle, North Carolina.

21.? Bengals:? D.J. Fluker, tackle, Alabama.

22. Rams:? Kenny Vaccaro, safety, Texas.

23.? Vikings:? D.J. Hayden, cornerback, Houston.

24.? Colts:? DeAndre Hopkins, receiver, Clemson.

25.? Jaguars (trade with Vikings):? Geno Smith, quarterback, West Virginia.

26. Packers:? John Jenkins, defensive tackle, Georgia.

27.? Texans:? Robert Woods, receiver, USC.

28.? Broncos:? Tank Carradine, defensive end, Florida State.

29.? Patriots:? Justin Hunter, receiver, Tennessee.

30.? Falcons:? Bjeorn Werner, defensive end, Florida State.

31.? 49ers:? Eric Reid, safety, LSU.

32.? Ravens:? Jonathan Cyprien, safety, FIU.

Source: http://profootballtalk.nbcsports.com/2013/04/09/team-by-team-draft-needs-2/related/

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Thursday, April 25, 2013

More severe concussion symptoms lead to longer recovery time

More severe concussion symptoms lead to longer recovery time [ Back to EurekAlert! ] Public release date: 25-Apr-2013
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Contact: Becky Lindeman
journal.pediatrics@cchmc.org
513-636-7140
Elsevier Health Sciences

Cincinnati, OH, April 25, 2013 -- Most children who suffer from sports-related concussions recover within a few days. However, in a small number of children, symptoms can last for a month or more. Although there have been numerous theories as to what might predict a longer recovery time, there is no definitive answer as to why it takes some children longer to recover. In a new study scheduled for publication in The Journal of Pediatrics, researchers attempted to identify risk factors that might predispose some children with concussions to longer recovery times.

Dr. William P. Meehan, III and colleagues from Boston Children's Hospital and the University of Pittsburgh Medical Center analyzed data from 182 patients who were seen at a sports concussion clinic within 3 weeks of injury. Patients completed the Post-Concussion Symptom Scale (PCSS), which contains 22 different symptoms that they ranked from 0-6 (0 = not experiencing a given symptom; 6 = describing the symptom as "severe"). Patients were separated into 2 groups: those who were symptom-free within 28 days and those who had symptoms for longer than 28 days. After analyzing data for numerous variables, including total score of the PCSS at initial visit, age, and amnesia symptoms, only the total score on the PCSS was independently associated with symptoms lasting longer than 28 days; the higher the score, the greater chance of a prolonged recovery time.

Although it is important for patients who suffer from prolonged symptoms of concussion to receive medical management, along with academic and occupational accommodations, most patients recover without needing these. Identifying risk factors for potentially prolonged recoveries will allow clinicians to coordinate the best treatment for patients. According to Dr. Meehan, "Parents, physicians, and caregivers of athletes who suffer from a high-degree of symptoms after a sports-related concussion should start preparing for the possibility of a prolonged recovery." Although some studies have shown longer recovery times in younger patients and patients who suffered from amnesia, results from this study do not suggest that age or amnesia are risk factors for prolonged recovery time. Instead, efforts to develop clinical tools for predicting which athletes will suffer prolonged recoveries after concussion should focus on initial symptom score.

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


More severe concussion symptoms lead to longer recovery time [ Back to EurekAlert! ] Public release date: 25-Apr-2013
[ | E-mail | Share Share ]

Contact: Becky Lindeman
journal.pediatrics@cchmc.org
513-636-7140
Elsevier Health Sciences

Cincinnati, OH, April 25, 2013 -- Most children who suffer from sports-related concussions recover within a few days. However, in a small number of children, symptoms can last for a month or more. Although there have been numerous theories as to what might predict a longer recovery time, there is no definitive answer as to why it takes some children longer to recover. In a new study scheduled for publication in The Journal of Pediatrics, researchers attempted to identify risk factors that might predispose some children with concussions to longer recovery times.

Dr. William P. Meehan, III and colleagues from Boston Children's Hospital and the University of Pittsburgh Medical Center analyzed data from 182 patients who were seen at a sports concussion clinic within 3 weeks of injury. Patients completed the Post-Concussion Symptom Scale (PCSS), which contains 22 different symptoms that they ranked from 0-6 (0 = not experiencing a given symptom; 6 = describing the symptom as "severe"). Patients were separated into 2 groups: those who were symptom-free within 28 days and those who had symptoms for longer than 28 days. After analyzing data for numerous variables, including total score of the PCSS at initial visit, age, and amnesia symptoms, only the total score on the PCSS was independently associated with symptoms lasting longer than 28 days; the higher the score, the greater chance of a prolonged recovery time.

Although it is important for patients who suffer from prolonged symptoms of concussion to receive medical management, along with academic and occupational accommodations, most patients recover without needing these. Identifying risk factors for potentially prolonged recoveries will allow clinicians to coordinate the best treatment for patients. According to Dr. Meehan, "Parents, physicians, and caregivers of athletes who suffer from a high-degree of symptoms after a sports-related concussion should start preparing for the possibility of a prolonged recovery." Although some studies have shown longer recovery times in younger patients and patients who suffered from amnesia, results from this study do not suggest that age or amnesia are risk factors for prolonged recovery time. Instead, efforts to develop clinical tools for predicting which athletes will suffer prolonged recoveries after concussion should focus on initial symptom score.

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-04/ehs-msc042213.php

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Sharon Osbourne Speaks Out On Ozzy Osbourne?s Relapse (VIDEO)

Sharon Osbourne Speaks Out On Ozzy Osbourne’s Relapse (VIDEO)

Ozzy Osbourne paranoia“The Talk” star Sharon Osbourne has spoken out about recent rumors that she and Ozzy Osbourne were getting divorced. Sharon said she is “devastated” about the rocker’s drug and alcohol use, but said they are not getting divorced. Sharon Osbourne said of her personal marital issues, “We?re dealing with it. We?re not getting divorced. However, ...

Sharon Osbourne Speaks Out On Ozzy Osbourne’s Relapse (VIDEO) Stupid Celebrities Gossip Stupid Celebrities Gossip News

Source: http://stupidcelebrities.net/2013/04/sharon-osbourne-speaks-out-on-ozzy-osbournes-relapse-video/

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Ricin suspect's attorney: He was framed (CNN)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/301243373?client_source=feed&format=rss

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Wednesday, April 24, 2013

Moneysaver PSA: Limited Time Gaming Deals For Tuesday - Kotaku

Set your iPhone's alarm, Amazon's got Gold Box deals on video games, and we've got all the details right here.

Starting at 3am EST, Amazon will be running limited time sales on several games and accessories. The deal ends either when time expires or when stock is sold through. We're going to list the offers below, times are all Eastern Standard. Thanks goes to Cheap Ass Gamer for the info. [Amazon Gold Box]

All Day
? PS3 God of War: Ascension ($40) | $55+ elsewhere
? PS3 God of War Legacy PS3 Bundle ($280) | $327+ elsewhere

3-8am
? 360 Gears of War: Judgment ($45) |

8-10am
? 360 Halo 4 ($30) | $38+ elsewhere

10am-12pm
? PS3/360 Hitman: Absolution ($19) | $31+ elsewhere

12-2pm
? PC/Mac Starcraft II: Wings of Liberty ($18) | $40+ elsewhere

2-3pm
? PS3/360 Dead Space 3 ($40) | This is currently $33 on Groupon, we'd advise you get it there.

3-5pm
? Tritton 720+ 7.1 Surround Headset for PS3 and 360 ($100) | $150+ elsewhere

5-7pm
? Turtle Beach Ear Force PX51 Premium Wireless Dolby Digital Gaming Headset ($200) | $222+ elsewhere

7-9pm
? 3DS/Vita Zero Escape: Virtue's Last Reward ($30) | $40+ elsewhere

9-11pm
? 360 Forza Horizon/Forza Horizon Limited Edition ($20) | $40 elsewhere | Why both versions are listed is not currently clear.

11pm-Midnight
? 360 Kinect Sports Ultimate Collection ($15) | $43+ elsewhere

Midnight-2am
? Lego Lord of the Rings ($20) | Which platforms is not currently clear, probably all of them.

Dig in, I'll update this throughout the day. Come back at 2:15pm for an all-new Moneysaver, and check out all the other deals in Monday's full Moneysaver roundup. Follow me on Kinja for deals as I post them, and check out Deals.Kinja.com for even more discounts.

Welcome to the new Moneysaver, now brought to you by the Commerce Team. Our aim is to bring Kotaku readers the best gaming deals available. And to be very clear, we also make money if you buy. We're making new improvements every day, and we want your feedback.

Basically every major release of the past several months is on sale today, and for every platform.? Read?

Source: http://kotaku.com/moneysaver-psa-limited-time-gaming-deals-for-tuesday-477584825

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Cigarette Makers Lose Challenge to Label Rule (WSJ)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/300858513?client_source=feed&format=rss

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Food & Drink Boulevard in Harlem May 2, 2013 | HarlemCondoLife

Harlem-Food-Drinks

Thursday, May 2, 2013 fdba (The Frederick Douglass Boulevard Alliance) invites you to their 2nd annual event: ?Food & Drink Boulevard. ?Summer Kick-Off and Evening of Food, Cocktails, Music and Entertainment on Harlem?s Restaurant Row.

Participants involved this year are:
1) Savann Restaurant
2) Chocolat
3) Bad Horse Pizza
4) Vinateria
5) Cedric
6) Lido
7) Levain Bakery
8) Harlem Tavern
9) Melba?s
10) Harlem Food Bar
11) Bier International
12) 67 Orange Street
13) 5 & Diamond

It will be held from 6pm ? 10pm along FDB up to 123rd Street. Cost is $10 at the door or $5 in advance. Information on tickets

Last years event was a lot of fun with DJ?s, live music, food & drink specials and additional entertainment. ?A great way to start summer off and meet people in your neighborhood. ?Invite your friends, have a good time at your favorite spots!

* Cond? Nast Traveller ?24 hours in Harlem? ? Did your favorite spot make the list?

Follow HarlemCondoLife on Twitter @HarlemHCL Your Gateway To Harlem.

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Source: http://harlemcondolife.com/2013/04/23/food-drink-boulevard-in-harlem-may-2-2013/?utm_source=rss&utm_medium=rss&utm_campaign=food-drink-boulevard-in-harlem-may-2-2013

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